Application of Methylprednisolone Sodium Succinate Combined with Tropisetron in Prevention of Nausea and Vomiting under Microvascular Decompression of Hemifacial Spasm / 中国医学科学院学报

Objective To evaluate the effect of methylprednisolone sodium succinate combined with tropisetron on postoperative nausea and vomiting(PONV)under microvascular decompression of hemifacial spasm.Methods From January to June 2019,485 patients undergoing microvascular decompression for facial spasm at Department of Neurosurgery,Peking University People's Hospital were randomly assigned into two groups with random number table method.For group A(n=242),2 ml saline was administrated by intravenous drip before induction and 5 mg tropisetron after operation.For group B(n=243),40 mg methylprednisolone sodium succinate was administrated by intravenous drip before induction and 5 mg tropisetron after operation.The anesthesia time,operation time,and incidence of PONV in 0-24 h and 24-48 h were recorded for the comparison of the remedial treatment rate of nausea and vomiting between the two groups.Results There was no significant difference in age,gender,smoking history,body mass index value,American Society of Anesthesiologists score,medical history,surgical side,PONV history,operation time or anesthesia time between the two groups(all P > 0.05).The incidence of PONV in group A was 35.5% and 18.2% during 0-24 h and 24-48 h,respectively,which was significantly higher than that(18.5%,χ

Analysis of curative effect of microvascular decompression in treating cranial nerve diseases under endoscope and microscope / 中华显微外科杂志

Objective To analyse the safety and effectiveness of microvascular decompression completely under endoscopy-assisted or microscope-assisted (EVD or MYD) for trigeminal neuralgia.Methods A retrospective analysis was conducted for patients who underwent completely EVD or MVD from January,2014 to September,2016.The clinical data,operative data and results were analyzed.The patients were divided into two groups according to the techniques.The all procedure of distinguishing the responsible vessels and decompressing which was done completely under endoscope were EVD group (n=141).Those being done completely under microscope were MVD group (n=125).All operations were done by same operator and same approach.Results The intracranial nerve symptoms disappeared in 137 cases(97.2％) in EVD group and 120 cases(96.0％) in MVD group.There were no severe operative complications such as intracranial infection,facial paralysis,intracranial hematoma and death.Mild hearing loss was happened in 2 cases (1.42％) in EVD group and 5 cases (4.00％) in MVD group;facial hypoesthesia,5 cases (3.54％) in EVD group,8 cases(6.40％) in MVD group;Transient ataxia,3 cases (2.13％) in EVD group,5 cases(4.00％) in MVD group;cerebrospinal fluid leakage,3 cases(2.13％) in EVD group,3 cases(2.40％) in MVD group;Oral herpes,23 cases (22.5％) in EVD group,27 cases(24.3％) in MVD group.There was no statistically significant differences in curative effect and complications between two groups (P＞ 0.05).Conclusion There is no difference in curative effect and complications between the two methods of completely EVD and MVD.